Zipeng Yang

Key Laboratory of Prevention and Control of Zoonotic Diseases of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

I have long been engaged in interdisciplinary research on Toxoplasma gondii, with a primary focus on:

• Pathogenic mechanisms of parasitism
• Development of parasite vaccines
• Molecular epidemiology and transmission dynamics
• Bioinformatics (genomics, transcriptomics, proteomics)
• Meta-analysis

By leveraging cutting-edge technologies (bioinformatics, transcriptomics, proteomics), I systematically investigate host-pathogen interactions and population genetics of Toxoplasma gondii, providing scientific foundations for precision prevention strategies in public health and veterinary medicine.

Published 30+ peer-reviewed papers, including 17 SCI-indexed articles (5 as first author) in journals such as International Immunopharmacology, Parasites & Vectors, Journal of Medical Virology, 《中国农业大学学报》, and 《中国兽医科学》

Main work

• Yang Z, Yuan H, Zhang XX, et al. The outbreak of the Ebola virus: Concerns for the animal-to-human spillover. J Med Virol. 2023;95(1):e28398. doi:10.1002/jmv.28398.
• Yang Z, Yuan H, He H, et al. Unlocking the role of EIF5A: A potential diagnostic marker regulating the cell cycle and showing negative correlation with immune infiltration in lung adenocarcinoma. Int Immunopharmacol. 2024; 126:111227. doi:10.1016/j.intimp.2023.111227.
• Yang Z, Yuan H, Nie L, Wen Q, et al. Deciphering the epidemiological dynamics: Toxoplasma gondii seroprevalence in mainland China's food animals, 2010-2023[J]. Front Cell Infect Microbiol, 2024b, 14: 1381537.
• Yang Z, Xu CP, Chen Y, Li W, Wang L, Yuan ZG. A Novel Mechanical-Based Injective Hydrogel for Treatment with Aromatase Inhibitors Caused Joint Inflammation via the NF-κB Pathway. ACS Omega. 2021;6(15):10242-10249. Published 2021 Apr 10. doi:10.1021/acsomega.1c00580.
• Ren, Z., Yang, Z., Yuan, H., Song, Y., He, H., Nie, L., Wang, X., Yuan, Z. G., & Zhang, X. X. (2024). 4D label-free proteomic analysis reveals key potential pathways of Toxoplasma invasion into the central nervous system. International immunopharmacology, 138, 112618. `https://doi.org/10.1016/j.intimp.2024.112618.`
• Zhang X, Yuan H, Yang Z, et al. SARS-CoV-2: An Updated Review Highlighting Its Evolution and Treatments. Vaccines (Basel). 2022;10(12):2145. Published 2022 Dec 14. doi:10.3390/vaccines10122145.
• Li H, Yuan H, Yang Z P, Song Y, et al. Correction: Differential transcriptome study on the damage of testicular tissues caused by chronic infection of T. gondii in mice[J]. Parasit Vectors, 2024, 17(1): 295.
• Yuan H, Zhang X X, Yang Z P, Wang X, et al. Unveiling of brain transcriptome of masked palm civet (Paguma larvata) with chronic infection of Toxoplasma gondii[J]. Parasit Vectors, 2022, 15(1): 263.
• Song Y, Yuan H, Yang X, Yang Z, et al. The opposing effect of acute and chronic Toxoplasma gondii infection on tumor development[J]. Parasit Vectors, 2024, 17(1): 247.
• Zhang X, Yuan H, Mahmmod YS, Yang Z et al. Insight into the current Toxoplasma gondii DNA vaccine: a review article. Expert Rev Vaccines. 2023;22(1):66-89. doi:10.1080/14760584.2023.2157818.
• Yan Z, Yuan H, Wang J, Yang Z et al. Four Chemotherapeutic Compounds That Limit Blood-Brain-Barrier Invasion by Toxoplasma gondii. Molecules. 2022;27(17):5572. Published 2022 Aug 30. doi:10.3390/molecules27175572.
• Yuan H, Jiang T, Zhang WD, Yang Z et al. Multiomics and bioinformatics identify differentially expressed effectors in the brain of Toxoplasma gondii infected masked palm civet. Front Cell Infect Microbiol. 2023;13:1267629. Published 2023 Sep 25. doi:10.3389/fcimb.2023.1267629.
• Wang J, Liu T, Mahmmod YS, Yang Z et al. Transcriptome Analysis of Testes and Uterus: Reproductive Dysfunction Induced by Toxoplasma gondii in Mice. Microorganisms. 2020;8(8):1136. Published 2020 Jul 28. doi:10.3390/microorganisms8081136.
• Cao H, Lin J, Yuan H, Yang Z, et al. The emerging role of Toxoplasma gondii in periodontal diseases and underlying mechanisms[J]. Front Immunol, 2024, 15: 1464108.
• Lan T, Fang D, Li H, Sahu, S. K, Wang, Q, Yuan, H, Zhu, Y, Yang Z et al. Chromosome-Scale Genome of Masked Palm Civet (Paguma larvata) Shows Genomic Signatures of Its Biological Characteristics and Evolution. Front Genet. 2022;12:819493. Published 2022 Jan 21. doi:10.3389/fgene.2021.819493.
• 姜云晶,杨子鹏,朱电锋,等.脱氧雪腐镰刀菌烯醇对PC12细胞自噬的影响[J].西北农林科技大学学报(自然科学版),2018,46(09):1-8.DOI:10.13207/j.cnki.jnwafu.2018.09.001.
• 孟婷婷,杨子鹏,王俊杰,等.弓形虫ME49虫株α-微管蛋白对神经瘤母细胞自噬的影响[J].中国兽医科学,2019,49(06):715-722.DOI:10.16656/j.issn.1673-4696.2019.0096.
• 聂林冲,袁浩,杨子鹏,等.锡兰钩虫ASP4基因的表达与免疫保护效果分析[J].中国农业大学学报,2024,29(11):102-111.
• 李贵峰,孟婷婷,杨子鹏,等.弓形虫H4和Rab2基因真核表达载体的构建及其对N2a细胞凋亡和自噬的影响[J].中国兽医科学,2019,49(05):580-588.DOI:10.16656/j.issn.1673-4696.2019.0062.
• 黄勉,冯伟利,植广林,杨子鹏等.不同宿主源弓形虫ROP16基因的遗传变异分析[J].中国农业科技导报,2020,22(07):117-123.DOI:10.13304/j.nykjdb.2019.0553.

Academic homepage

• Frontiers loop: https://loop.frontiersin.org/people/2600662/overview
• Google scholar： https://scholar.google.com/citations?user=jGoagNgAAAAJ&hl=zh-CN
• ORICD： https://orcid.org/0000-0002-7711-3260

Other Scholarly Contributions

• Reviewer for Animal and Veterinary Sciences & Medical Research Frontiers, completed 10+ manuscript reviews, demonstrating extensive peer-review experience.
• First Co-Editor of Knowledge Atlas on the Prevention and Control of Common Zoonotic Parasitic Diseases (in Chinese, ISBN: 978-7-5655-3341-9), a key reference for veterinary medicine and public health.